期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 139, 期 6, 页码 1830-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2016.09.024
关键词
Allergy immunotherapy; allergic rhinitis; grass pollen; Phleum pratense; immunotherapy; intradermal; low dose
资金
- Efficacy and Mechanism Evaluation Programme
- Medical Research Council (MRC)
- King's College London
- Guy's & St Thomas' NHS Foundation Trust
- NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust
- United Kingdom Clinical Research Collaboration-registered King's Clinical Trials Unit at King's Health Partners
- NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust
- NIHR Evaluation, Trials and Studies Coordinating Centre
- HEFCE Clinical Senior Lectureship Award
- MRC-Asthma UK
- Athena SWAN
- Royal College of Surgeons (England)
- NIHR Leicester Respiratory Biomedical Research Unit
- Medical Research Council [G1000758, MC_PC_12038] Funding Source: researchfish
- MRC [MC_PC_12038] Funding Source: UKRI
Background: Repeated low-dose grass pollen intradermal allergen injection suppresses allergen-induced cutaneous late-phase responses comparably with conventional subcutaneous and sublingual immunotherapy. Objective: We sought to evaluate the efficacy and safety of grass pollen intradermal immunotherapy in the treatment of allergic rhinitis. Methods: We randomly assigned 93 adults with grass pollen-induced allergic rhinitis to receive 7 preseasonal intradermal allergen injections (containing 7 ng of Phl p 5 major allergen) or a histamine control. The primary end point was daily combined symptom-medication scores during the 2013 pollen season (area under the curve). Analysis was by intention to treat. Skin biopsy specimens were collected after intradermal allergen challenges, and late-phase responses were measured 4 and 7, 10, or 13 months after treatment. Results: There was no significant difference in the primary end point between treatment arms (active, n = 46; control, n = 47; median difference, 14; 95% CI, -172.5 to 215.1; P = .80). Among secondary end points, nasal symptoms were worse in the intradermal treatment group, as measured based on daily (median difference, 35; 95% CI, 4.0-67.5; P = .03) and visual analog scale (median difference, 53; 95% CI, -11.6 to 125.2; P = .05) scores. In a per-protocol analysis intradermal immunotherapy was further associated with worse asthma symptoms and fewer symptom-free days. Intradermal immunotherapy increased serum Phleum pratense-specific IgE levels (P = .001) compared with those in the control arm. T cells cultured from biopsy specimens of subjects undergoing intradermal immunotherapy had higher expression of the T(H)2 surface marker CRTH2 (P = .04) and lower expression of the T(H)1 marker CXCR3 (P = .01), respectively. Late-phase responses remained inhibited 7 months after treatment (P = .03). Conclusion: Intradermal allergen immunotherapy suppressed skin late-phase responses but was not clinically effective and resulted in worsening of respiratory allergic symptoms.
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