期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 139, 期 4, 页码 1084-1091出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2017.02.011
关键词
Allergy; microbiota; early-life; window of opportunity; neonate
资金
- National Institutes of Health [RO1 DK44319]
- Harvard Digestive Diseases Center
- Crohn's and Colitis Foundation of America [418509]
Early postnatal life is a key time for development of the immune system and colonization of the host by microbiota. Recent studies have shown that specific limbs of the immune system can be regulated by microbiota in a time-restricted period during early life. Studies in mouse models have shown that perturbations of the microbiota during early life can cause immune effects that can persist into adulthood and create increased host susceptibility to certain diseases. Here we discuss the role of early-life regulation of the immune system by the microbiota and how it can be related to allergy development.
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