期刊
ANALYST
卷 145, 期 3, 页码 873-879出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9an01904a
关键词
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资金
- National Key Research and Development Program of China [2016YFA0201300]
- National Natural Science Foundation of China [21575006]
In this work, an Au-Ag alloy nanourchin (Au-Ag alloy NU) based electrochemiluminescent (ECL) sensor for the measurement of cardiac troponin I (cTnI) was developed. The as-prepared Au-Ag alloy NUs exhibited higher specific surface area and better conductivity owing to their unique urchin-like morphology, which resulted in excellent electrocatalytic activity towards H2O2 in the luminol-H2O2 ECL system. We have found that the Au-Ag alloy NUs could enhance the ECL signal in the luminol-H2O2 solution. Based on these facts, a facile and label-free ECL immunosensor has been constructed for the analysis of cTnI, a cardiac biomarker, with a wide linear range of 3.5 pg mL(-1)-350 mu g mL(-1). This novel ECL immunosensor has good stability and reproducibility, showing potential application in clinical diagnostics. In addition, a non-enzymatic electrochemical sensor for H2O2 was also fabricated, with a wide linear detection range of 100 nM-200 mu M, a low limit of detection of 45 nM and a fast response time (less than 2 s).
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