期刊
ANALYST
卷 145, 期 3, 页码 797-804出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9an02231g
关键词
-
资金
- National Natural Science Foundation of China (NSFC) [21976166, 31771077, 21405144]
- Science Challenge Project [TZ2016004]
- General Research fund (GRF) of Research Grant Council of Hong Kong [15210818]
- Hong Kong Polytechnic University Internal Fund [1-ZVJ7, 1-YW1L]
- University Research Facility in Life Sciences of The Hong Kong Polytechnic University
Detecting trace amounts of copper ions (Cu2+) is of high importance since copper is an essential element in the environment and the human body. Despite the recent advances in Cu2+ detection, the current approaches still suffer from insensitivity and lack of in situ detection in living cells. In the present work, a fluorescent nanosensor based on porphyrinic metal-organic framework nanoparticles (MOF-525 NPs) is proposed for sensitive and selective monitoring of Cu2+ in aqueous solution and living cells. The MOF-525 NPs with attractive properties, including ultrasmall size, good water dispersity and intense red fluorescence, are prepared via a facile and environment-friendly hydrothermal route. The fluorescence signal of MOF-525 NPs could be quenched statically by Cu2+ with high selectivity due to the strong affinity of Cu2+ to the porphyrin ligand in MOF-525. The proposed fluorescent nanosensor has a linear response in the range of 1.0-250 nM with a low detection limit of 220 pM. Furthermore, it is successfully employed for the detection of Cu2+ in water samples and the intracellular imaging of Cu2+ in living cells, demonstrating its great potential in the sensing and biological fields.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据