期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 26, 期 2, 页码 121-131出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2014.12.006
关键词
Interferon; Viral infection; Cancer; Interferon therapy; Resistance to interferon therapy
The clinical exploitation of type I interferon (IFN) as an antiviral and antineoplastic agent is based on the properties originally attributed to this cytokine family, with schedules reflecting only their antiviral and antiproliferative activities. Nevertheless, type I IFN has emerged as a central activator of the innate immunity. As current schedules of treatment for chronic hepatitis C and for hematological and solid tumors, based on the continuous administration of recombinant type I IFN or pegylated formulations, disregard viral resistance, host genetic variants predicting treatment outcome and mechanisms of refractoriness, new administration schedules, the combination of type I IFN with new drugs and the increased monitoring of patients' susceptibility to type I IFN are expected to provide a new life to this valuable cytokine. (C) 2015 Elsevier Ltd. All rights reserved.
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