期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 26, 期 4, 页码 405-413出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2015.04.002
关键词
Cytokine; Estrogen; Sex hormone; SIAH1; SIAH2
资金
- Deutsche Forschungsgemeinschaft [KR 2291/4-1/MA 2183/1-1, GRK1739/1 Kna]
- German Cancer Aid [110909, 110125]
- Wilhelm Sander-Stiftung [2010.078.2]
- University Medical Center, Mainz, Germany
The ubiquitin-dependent proteasomal degradation of proteins controls signaling and cellular survival. An increasing body of evidence suggests that the E3 ubiquitin ligases SIAH1 and S1AH2 are able to dictate the growth, development, and chemo-/radiosensitivity of breast and prostate cancer cells. Here we review the current knowledge on the impact of S1AHs on breast and prostate tumorigenesis. Furthermore, we summarize how stress, hormones, and cytokines regulate SIAH1 and SIAH2 in transformed mammalian cells. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据