期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 26, 期 5, 页码 595-602出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2015.07.002
关键词
Systems biology; Mathematical modeling; IL-6-type cytokines; Quantitative analyses
资金
- German Federal Ministry of Education and Research (BMBF): E:Bio-Modul I JAK-Sys
- German Federal Ministry of Education and Research (BMBF): E:Bio-Modul II InTraSig
Interleukin-6-type cytokines play important roles in the communication between cells of multicellular organisms. They are involved in the regulation of complex cellular processes such as proliferation and differentiation and act as key player during inflammation and immune response. A major challenge is to understand how these complex non-linear processes are connected and regulated. Systems biology approaches are used to tackle this challenge in an iterative process of quantitative experimental and mathematical analyses. Here we review quantitative experimental studies and systems biology approaches dealing with the function of Interleukin-6-type cytokines in physiological and pathophysiological conditions. These approaches cover the analyses of signal transduction on a cellular level up to pharmacokinetic and pharmacodynamic studies on a whole organism level. (C) 2015 Elsevier Ltd. All rights reserved.
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