期刊
CYTOKINE
卷 75, 期 2, 页码 280-290出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2015.05.005
关键词
Interleukin-1 family; Obesity; Inflammation; Insulin resistance; Adipose tissue
资金
- Netherlands Organization for Scientific Research (NWO) [016.136.311]
- NIH [AI-1561]
- Dutch Diabetes Research Foundation [2013.81.1674]
- Interleukin-1 foundation
Obesity is characterized by a chronic, low-grade inflammation that contributes to the development of insulin resistance and type 2 diabetes. Cytokines and chemokines produced by immunocompetent cells influence local as well as systemic inflammation and are therefore critical contributors to the pathogenesis of type 2 diabetes. Hence, cytokines that modulate inflammatory responses are emerging as potential targets for intervention and treatment of the metabolic consequences of obesity. The interleukin-1 (IL-1) family of cytokines and receptors are key mediators of innate inflammatory responses and exhibit both pro- and anti-inflammatory functions. During the last decades, mechanistic insights into how the IL-1 family affects the initiation and progression of obesity-induced insulin resistance have increased significantly. Here, we review the current knowledge and understanding, with emphasis on the therapeutic potential of individual members of the IL-1 family of cytokines for improving insulin sensitivity in patients with diabetes. (C) 2015 Elsevier Ltd. All rights reserved.
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