期刊
NANOSCALE
卷 12, 期 14, 页码 7960-7968出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr00572j
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类别
资金
- National Natural Science Foundation of China [31871004, 31571022]
- Ministry of Science and Technology of China [2016YFA0201600, 2016YFE0133100]
- Program for International S&T Cooperation Projects of the Ministry of Science and Technology of China [2018YFE0117200]
- Science Fund for Creative Research Groups of the National Natural Science Foundation of China [11621505]
- Bureau of International Co-operation Chinese Academy of Sciences [GJHG1852]
- CAS interdisciplinary innovation team
Metal ions are essential components that help maintain the processes of normal life, and they can be used to fabricate self-assembled building blocks for peptide derivatives, proteins and nucleic acids. Here, we have developed a novel strategy to construct supramolecular hydrogels modulated using metal cations. Upon introducing a variety of metal ions into aqueous solutions of a gelator (naproxen-FF), including a nonsteroidal anti-inflammatory drug (NSAID) and dipeptide, we obtain stable hydrogels under neutral or alkaline conditions. It is found that these hydrogels with three-dimensional nanofiber networks exhibit excellent mechanical properties and thixotropy, as well as superb responsivity to multiple metal ions. Due to the significance of potassium ions in biological processes, the K-triggered hydrogel has been chosen as a model, and its self-assembly mechanism has been explored via various spectral analysis processes. In addition, the self-assembly performances of peptides are significantly affected by the chemical structures of the gelator molecules. This work provides deep insight into the aggregation mechanism of dipeptide-conjugating drug molecules through introducing a variety of metal ions, laying the foundation for further biological applications.
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