期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 65, 期 18, 页码 3665-3674出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.7b00276
关键词
Dendrobium nobile; dendrobine; antiviral; viral nucleoprotein; influenza A virus
资金
- Natural Science Foundation of Guangdong Province [2016A030313591]
- National Natural Science Foundation of China [U1301224]
- Pearl River S&T Nova program of Guangzhou [2014J2200033]
Dendrobine, a major component of Dendrobium nobile, increasingly draws attention for its wide applications in health care. Here we explore potential effects of dendrobine against influenza A virus and elucidate the underlying mechanism. Our results indicated that dendrobine possessed antiviral activity against influenza A viruses, including A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1), and A/Aichi/2/68 (H3N2) with IC50 values of 3.39 +/- 0.32, 2.16 +/- 0.91, 5.32 +/- 1.68 mu g/mL, respectively. Mechanism studies revealed that dendrobine inhibited early steps in the viral replication cycle. Notably, dendrobine could bind to the highly conserved region of viral nucleoprotein (NP), subsequently restraining nuclear export of viral NP and its oligomerization. In conclusion, dendrobine shows potential to be developed as a promising agent to treat influenza virus infection. More importantly, the results provide invaluable information for the full application of the Traditional Chinese Medicine named Shi Hu.
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