期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 65, 期 32, 页码 6929-6935出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.7b00987
关键词
dielectric barrier discharge; atmospheric pressure plasma; quercetin; (+/-)-alphitonin; alpha-glucosidase; radical scavenging
资金
- R&D Program of Plasma Advanced Technology for Agriculture and Food (Plasma Farming)through the National Fusion Research Institute of Korea (NFRI) - government funds, National Research Foundation of Korea [En1425-1, NRF-2015H1A2A1034708]
- Basic Science Research Program of the National Research Foundation of Korea (NRF)
- Ministry of Science [2017R1A2B4003145]
- National Research Foundation of Korea [2017R1A2B4003145] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Nonthermal plasma is a promising technology to improve the safety and to extend the shelf-life of various minimally processed foods. However, research on plasma-induced systemic degradation related to changes in chemical structure and biological activity is still very limited. In this study, the enhancement of biological activity and the mechanism of degradation of the most common type of flavonol, quercetin, induced by a dielectric barrier discharge (DBD) plasma were investigated. Quercetin is dissolved in methanol and exposed to nonthermal DBD plasma for 5, 10, 20, and 30 min. The quercetin treated with the plasma for 20 min showed rapidly increased alpha-glucosidase inhibitory and radical scavenging activities compared to those of parent quercetin. The structures of the degradation products 13 from the quercetin treated with the plasma for 20 min were isolated and characterized by interpretation of their spectroscopic data. Among the generated products, (+/-)-alphitonin (1) exhibited significantly improved antidiabetic and antioxidant properties compared to those of the parent quercetin. The antidiabetic and antioxidant properties were measured by alpha-glucosidase inhibition and 1,1-diphenyl-2-picrylhydrazyl radical scavenging assays. These results suggested that structural changes in quercetin induced by DBD plasma might be attributable to improving the biological activity.
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