期刊
CYTOKINE
卷 75, 期 1, 页码 38-50出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2015.05.023
关键词
Interleukin-4; Interleukin-13; Singling; Regulation; Receptor
资金
- NHLBI NIH HHS [R00 HL096897] Funding Source: Medline
Interleukin (IL)-4 and IL-13 were discovered approximately 30 years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development and neurological function and in the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their receptors has revealed important clues about cytokine biology and led to the development of numerous experimental therapeutics. Here we aim to highlight new discoveries and consolidate concepts in the field of IL-4 and IL-13 structure, receptor regulation, signaling and experimental therapeutics. (C) 2015 Elsevier Ltd. All rights reserved.
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