期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 65, 期 8, 页码 1550-1555出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b05238
关键词
sesquiterpenoid; laurane; red alga; axial chirality; PTP1B
资金
- Natural Science Foundation of China [81520108028, 81273430, 41306130, 81302692, 41676073, 81603022]
- SCTSM Project [14431901100, 15431901000]
- Institutes for Drug Discovery and Development
- Chinese Academy of Sciences [CASIIVIM0120152039]
- SKLDR/SIMM Projects [SIMM 1501ZZ-03]
- Youth Innovation Promotion Association from the Chinese Academy of Sciences [2016258]
- Young Talent Supporting Project from the China Association for Science and Technology [2016QNRC001]
- Shanghai Pujiang Program [16PJ1410600]
- EU
- European Regional Development Fund [GINOP-2.3.2-15-2016-00008]
Three novel heterodimeric laurane-type sesquiterpenoids, laurokamurols A-C (1-3), along with eight known related monomeric ones (4-11) were isolated from the East China Sea red alga Laurencia okamurai Yamada. The absolute configurations of the new bis-sesquitepenoids, especially their axial chirality, were determined by extensive spectroscopic analyses and TDDFT-ECD method. All of the new compounds showed promising PTP1B inhibitory activities with IC50 values comparable to the positive control, indicating them as potential food additives or pharmaceutical drug leads toward obesity or diabetes.
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