期刊
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
卷 6, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s40942-020-00212-5
关键词
Aflibercept; Ranibizumab; Age-related macular degeneration; Vascular endothelial growth factor
Background: To evaluate the change in best corrected visual acuity (VA) and central macular thickness (CMT) following treatment with intravitreal aflibercept (AFL) in patients poorly responders or non responders to ranibizumab (RBZ). Methods: Charts of patients injected with RBZ from January 2016 to December 2018 (548 cases) due to neovascular age-related macular degeneration (nAMD) were reviewed. Fifty-six cases met our criteria for poor responders to RBZ (CMT decreased between 5 and 15% over treatment) or for non responders to RBZ (CMT decreased less than 5% or increased over treatment). Results: After the third AFL injection, CMT decreased from 384.38 +/- 123.20 mu m to 296.18 +/- 70.52 mu m in the nonresponder group and from 320.00 +/- 82.05 mu m to 282.27 +/- 56.86 mu m in the poor responder group. Although decrease in macular thickness was overall achieved 3 months after switching to AFL, it was not translated in VA improvement. Conclusions: it was observed that nAMD patients classified as RBZ non-responders tend to respond better to AFL than RBZ poor-responders anatomically, without correspondent improvement in VA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据