期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 65, 期 23, 页码 4691-4697出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.7b00981
关键词
biotraasformations; UGT73B6(FS); E. coli phenolic glucosides
资金
- National Natural Science Foundation of China [21302214]
- 973 Program of China [2012CB721100]
- Biological Resources Service Plan of CAS [ZSTH-023]
Three rosmarinic acid analogs produced by recombinant Escherichia coli, two xanthones from fungi and honokiol from plants, were explored as the substrates of E. coli harboring a glucosyltransferase mutant UGT73B6(FS) to generate phenolic glucosides. Six new and two known compounds were isolated from the fermentation broth of the recombinant strain of the feeding experiments, and the compounds were identified by spectroscopy, The biotransformation of rosmarinic acid analogs and 'xanthones into corresponding glucosides was presented for the first time This study not only demonstrated the substrate flexibility of the glucosyltransferase mutant UGT73B6(FS) toward aromatic alcohols :but also provided an effective and economical method to produce phenolic glucosides by fermentation circumventing: the use of expensive precursor UDP-glucose.
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