期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 65, 期 32, 页码 6831-6839出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.7b02171
关键词
oat phenolics; avenanthramides; LC-MS; Caco-2; alpha-amylase
资金
- General Mills Inc.
- Ingestive Behavior Research Center of Purdue University
Four oat varieties and three prothict forms (porridge, cereal, and snack bar) were assessed to determine the impact of oat phenolics on starch digestibility and intestinal glucose transport. alpha-Amylase activity was enhanced by 20 GAE mu M (gallic acid equivalent) of phenolics extracted from oat (96.7-118%, p < 0.05), while it was modestly inhibited at 500 GAE mu M (83.0-95.4%). Maltose hydrolysis was reduced (49.6-82.4%, p < 0.05), albeit with high IC50 values (500-940 GAE mu M). Free and bound oat phenolic extracts dose-dependently attenuated transport of D-glucose-1,2,3,4,5,6,6-d(7) by Caco-2 monolayers over 60 min. Oat foods were then subjected to a coupled in vitro digestion/Cato-2 intestinal cell model to determine relevance to whole food systems. Digestive release of glucose was similar among products; however, glucose transport was significantly reduced from digesta of GMI 423 porridge and puffed cereal by 34% +/- 12% and 20% +/- 10% (p < 0.05) at 60 min. Results suggest phenolics might be a factor modulating glycemic response of oat products.
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