期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 65, 期 46, 页码 10011-10019出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.7b03764
关键词
exopolysaccharides; beta-glucan; obesity; Akkermansia; intestinal microbiota
资金
- National Research Foundation of Korea (NRF) grant - the Korea government (MSIP) [2015R1A2A2A01005017]
- National Research Foundation of Korea [2015R1A2A2A01005017] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Physiological properties of water-soluble exopolysaccharides (EPS) and residues after EPS removal (Res) from the probiotic kefir were determined in high-fat (HF) diet-fed CS7BL/6J mice. EPS solutions showed rheological properties and lower viscosity compared to those of,beta-glucan (BG). EPS significantly suppressed the adipogenesis of 3T3-L1 preadipocytes in a dose-dependent manner. Mice were fed HF diets containing 5% EPS, 5% BG, 8% Res, or 5% microcrystalline cellulose (control) for 4 weeks. Compared with the control, EPS supplementation significantly reduced HF diet-induced body weight gain, adipose tissue weight, and plasma very-low-density lipoprotein cholesterol concentration (P < 0.05). Res and BG significantly reduced body weight gain; however, reduction in adipose tissue weight was not statistically significant, suggesting that the antiobesity effect of EPS occurs due to viscosity and an additional factor. EPS supplementation significantly enhanced abundance of Akkermansia spp. in feces. These data indicate that EPS shows significant antiobesity effects possibly via intestinal microbiota alterations.
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