期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 5, 页码 3378-3389出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00299
关键词
immunogenic cell death; hyaluronidase; chemo-immunotherapy; doxorubicin; extracellular matrix
资金
- National Natural Science Foundation of China [81972565]
- Program for HUST Academic Frontier Youth Team [2015-01]
The chemo-immunotherapy has become a highly prospective method for cancer treatment, and it has been known that chemotherapeutic drugs [e.g., doxorubicin (DOX)] could trigger antitumor immune responses. Yet, insufficient tumor penetrability and weak immunogenic cell death (ICD) severely limits the therapeutic effect of chemo-immunotherapy against cancer. Herein, we report the design of DOX-loaded silica nanocarriers (DOX@HMSPHs) with hyaluronidase functionalization, which could increase the permeability of drug and induce enhanced ICD effect through the degradation of hyaluronic acid (HA) in the extracellular matrix (ECM). Interestingly, the controlled release of DOX from DOX@HMSPHs in the acidic microenvironment induced ICD of tumor cells to release tumor antigens and damage -associated molecular patterns, promoting the antigen-presentation of dendritic cells (DCs) and the activation of specific tumor immunity. Moreover, HMSPHs could be used as an immune adjuvant to promote maturation of DCs, thereby promoting the activation of tumor infiltrating cytotoxic T lymphocytes. This strategy presents a concept to improve the efficacy of chemo-immunotherapy through degradation of HA in the ECM.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据