期刊
LIFE SCIENCE ALLIANCE
卷 3, 期 4, 页码 -出版社
LIFE SCIENCE ALLIANCE LLC
DOI: 10.26508/lsa.201900632
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资金
- Canadian Institutes of Health Research
- Fonds de Recherche du Quebec-Sante (FRQ-S)
- Spanish Ministry of Economy and Competitiveness [BFU2015-68741]
- Catalan Government [2017 SGR 799]
- Marato de TV3 [TV913-20131430]
- Centre of Excellence Severo Ochoa
In animals, miRNAs are the most prevalent small non-coding RNA molecules controlling posttranscriptional gene regulation. The Argonaute proteins (AGO) mediate miRNA-guided gene silencing by recruiting multiple factors involved in translational repression, deadenylation, and decapping. Here, we report that CSDE1, an RNA-binding protein linked to stem cell maintenance and metastasis in cancer, interacts with AGO2 within miRNA-induced silencing complex and mediates gene silencing through its N-terminal domains. We show that CSDE1 interacts with LSM14A, a constituent of P-body assembly and further associates to the DCP1-DCP2 decapping complex, suggesting that CSDE1 could promote the decay of miRNA-induced silencing complex-targeted mRNAs. Together, our findings uncover a hitherto unknown mechanism used by CSDE1 in the control of gene expression mediated by the miRNA pathway.
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