期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 37, 页码 5058-5061出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc00641f
关键词
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资金
- Shanghai Institute of Organic Chemistry
- State Key Laboratory of Organometallic Chemistry
- National Natural Science Foundation of China [21821002]
Using thianthrene S-oxide (TTSO) as a transient mediator, para-arylation and alkenylation of mono-substituted arenes have been demonstrated via a para-selective thianthrenation/Pd-catalyzed thio-Suzuki-Miyaura coupling sequence under mild conditions. This reaction features a broad substrate scope, and functional group and heterocycle tolerance. The versatility of this approach was further demonstrated by late-stage functionalization of complex bioactive scaffolds, and direct synthesis of some pharmaceuticals, including Tetriprofen, Ibuprofen, Bifonazole, and LJ570.
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