期刊
JAPANESE JOURNAL OF RADIOLOGY
卷 35, 期 5, 页码 269-278出版社
SPRINGER
DOI: 10.1007/s11604-017-0630-2
关键词
Prostate cancer; Hypofractionation; Intensity modulated radiotherapy; Acute toxicity; Late toxicity
资金
- Health and Labour Sciences Research Grants [H26-Cancer Policy-General-014]
- Grants-in-Aid for Scientific Research [16H07429, 15K19212] Funding Source: KAKEN
Purpose The present study compared the complications associated with hypofractionated intensity-modulated radiation therapy (Hypo-IMRT) of prostate cancer to conventionally fractionated IMRT (Conv-IMRT). Materials and methods Hypo-IMRT delivered 70 Gy in 28 fractions, whereas Conv-IMRT delivered 78 Gy in 39 fractions. Toxicity was graded with the Common Terminology Criteria for Adverse Events, version 4.0, weekly during radiotherapy, 1 month after radiotherapy, and annually in both patient groups. Results The median follow-ups were 39.1 and 38.7 months for patients in the Hypo-and Conv-IMRT groups, respectively. There was no significant difference in rates of acute and late adverse events. The proportions of grade 2 acute genitourinary complications were 48.4 and 51.2% in the Hypo-and Conv-IMRT groups, respectively. The presence of a baseline International Prostate Symptom Score (IPSS) of ten or more was the only significant prognostic factor for grade 2 acute genitourinary toxicity. The incidence of grade 2 late rectal hemorrhage at 3 years was 3.2 and 3.5% in the Hypo-and Conv-IMRT groups, respectively. Small rectal volume was significantly associated with grade 2 late rectal hemorrhage. Conclusion Regarding acute and late adverse events, hypofractionated IMRT for prostate cancer was well tolerated and comparable with conventionally fractionated IMRT.
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