期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 15, 期 12, 页码 1082-1101出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026615666150413153143
关键词
Affibodies; Affilins; Anticalins; Armadillo repeat; Atrimers; Avimers; Cell display; Combinatorial libraries; Darpins; Directed evolution; DNA display; Fynomers; Knottins; Kunitz domain; Monobodies; mRNA display; OBodies; Phage display; Peptide aptamers; Protein scaffold; Ribosome display; Thioredoxin; Yeast two hybrid
资金
- NIH [R01GM08500605]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM085006] Funding Source: NIH RePORTER
Peptide aptamers are small combinatorial proteins that are selected to bind to specific sites on their target molecules. Peptide aptamers consist of short, 5-20 amino acid residues long sequences, typically embedded as a loop within a stable protein scaffold. Various peptide aptamer scaffolds and in vitro and in vivo selection techniques are reviewed with emphasis on specific biomedical, bioimaging, and bioanalytical applications.
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