期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 15, 期 5, 页码 446-457出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026615666150114160543
关键词
Alzheimer's disease; Amyloid beta; Cytokines; NF-kappa B; Oxidative stress; Redox signaling
Oxidative stress and inflammatory response are important elements of Alzheimer's disease (AD) pathogenesis, but the role of redox signaling cascade and its cross-talk with inflammatory mediators have not been elucidated in details in this disorder. The review summarizes the facts about redox-signaling cascade in the cells operating through an array of kinases, phosphatases and transcription factors and their downstream components. The biology of NF-kappa B and its activation by reactive oxygen species (ROS) and proinflammatory cytokines in the pathogenesis of AD have been specially highlighted citing evidence both from post-mortem studies in AD brain and experimental research in animal or cell-based models of AD. The possibility of identifying new disease-modifying drugs for AD targeting NF-kappa B signaling cascade has been discussed in the end.
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