期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 36, 页码 4934-4937出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/D0CC01220C
关键词
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资金
- Natural Science Foundation of Jiangsu Province [BK20190213]
- Wuhan Morning Light Plan of Youth Science and Technology [2017050304010307]
- Shenzhen Science and Technology Innovation Committee [KQTD20150717103157174]
Highly efficient Ni-catalyzed asymmetric hydrogenation of cyclic N-sulfonyl ketimino esters was, for the first time, successfully developed, providing various chiral alpha-monosubstituted alpha-amino acid derivatives with excellent results (97-99% yields, 90 to >99% ee). Cyclic N-sulfonyl ketimines were also hydrogenated well to afford chiral amine derivatives with 98-99% yields and 97 to >99% ee. The gram-scale asymmetric hydrogenation was performed well with 85% yield and 99% ee using only 0.2 mol% catalyst.
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