期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 15, 期 23, 页码 2342-2372出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026615666150619142731
关键词
Dipeptidyl peptidase-IV inhibitors; Pharmacokinetic properties; Physico-chemical properties; SAR; Toxicological properties; Type 2 diabetes mellitus
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [OI 172044, TR 31060]
- Slovenian Research Agency [P1-0208]
Dipeptidyl peptidase-IV (DPP-IV) (EC 3.4.14.5) is. member of the broad class of hydrolytic enzymes which is responsible for degradation of the incretin peptide hormones regulating blood glucose levels. In this article we review the literature on natural and synthetic DPP-IV inhibitors, focusing their chemical structure and mechanism of action. Further, physico-chemical, pharmacokinetic and toxicological properties of DPP-IV inhibitors are calculated and compared. On the basis of literature data we selected the DPP-IV inhibitors with IC50 values below 1 nM and discussed their possible application in therapy of type 2 diabetes mellitus.
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