期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 15, 期 19, 页码 1947-1956出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026615666150515145733
关键词
G-quadruplex; RNA; Drug targets; Biological function; DNA
资金
- National Natural Science Foundation of China [21372263]
- Fundamental Research Funds for the Central Universities [11ykzd04]
- Zhujiang Nova Program [2011J2200075]
- Foundation for Distinguished Young Talents in Higher Education of Guangdong [Yq2013002]
Roles of RNA on transcriptional and post-transcriptional regulations have raised more attention since the new era of genomics. One of the secondary structures of RNA, the RNA G-quadruplex structure, is demonstrated a relatively stable existence in human tumor cells, virus, or other species relating to diseases. G-quadruplexes are special secondary structures formed by G-rich DNA and RNA sequences that fold into a four-stranded conformation. The G-quadruplexes formed in RNA are involved in many biological process including telomere elongation, transcription regulate, pre-mRNA splicing and translation. In this review, we will give a brief introduction to the structures of RNA G-quadruplexes, the biological roles and the potential to be as drug targets.
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