期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 15, 期 21, 页码 2193-2210出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026615666150610142027
关键词
Gut-brain axis; Inflammatory bowel disease; Microglia; Neurodegeneration; Parkinson's disease; Peripheral inflammation
资金
- Junta de Andalucia [P10-CTS-6494]
- Ministerio de Economia y Competitividad [SAF2012-39029]
Neurodegenerative diseases are characterized by a progressive deterioration of brain function, with a consequent significant decline in the quality of life of patients and their families. Due to the concurrent increase in life expectancy, the incidence of these diseases has been increasing over the last years and thus there is a growing interest in finding potential risk factors. This review focuses on the correlation between peripheral inflammatory diseases and neurodegeneration, in particular on the relationship between gastrointestinal disorders and Parkinson's disease, especially through the so called gut-brain axis.
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