期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 15, 期 10, 页码 927-938出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802661510150328223655
关键词
Kinase inhibitors; Leucine-rich repeat kinase 2 (LRRK2); Parkinson's disease
Mutations in the gene for leucine-rich repeat kinase 2 (LRRK2) have been linked to several familial and sporadic late-onset cases of Parkinson's disease. The cumulative data for the effects of mutant forms of this enzyme on neuronal degradation and the pathophysiology of Parkinson's disease create a compelling case for drug discovery based on inhibition of the mutant forms of LRRK2. This review focuses on structure-activity relationships for inhibitors of LRRK2 and the data supporting a potential role of these agents in treating Parkinson's disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据