期刊
GENES & DISEASES
卷 7, 期 2, 页码 166-171出版社
ELSEVIER
DOI: 10.1016/j.gendis.2019.09.011
关键词
Lysine succinylation; Metabolism; Post-translational modification; SIRT5; Succinyl-CoA
资金
- NIH [R01 CA225680-01]
- American Cancer Society [RSG-19-076-01-TBE]
- Susan G. Komen Foundation [CCR14300798]
- Eagles Cancer Research Fund
- Team Science Platform Award from the Mayo Clinic Center for Biomedical Discovery
- Developmental Therapeutics Program from the Mayo Clinic Cancer Center
- Mayo Clinic Breast [SPOREP 50CA 116201-10]
- Mayo Foundation for Education and Research
Lysine succinylation (Ksucc), defined as a transfer of a succinyl group to a lysine residue of a protein, is a newly identified protein post-translational modification(1-3). This chemical modification is reversible, dynamic, and evolutionarily conserved (4) where it has been comprehensively studied in both bacterial and mammalian cells(5-7). Numerous proteins involved in the regulation of various cellular and biological processes have been shown to be heavily succinylated(5-7). Emerging clinical data provides evidence that dysregulation of Ksucc is correlated with the development of several diseases, including cardiovascular diseases and cancer(7-9). Therefore, an in-depth understanding of Ksucc and its regulation is important not only for understanding its physiological function but also for developing drug therapies and targeted agents for these diseases. In this review, we highlight some of the recent advances in understanding the role of Ksucc and desuccinylation under physiological and pathological conditions. Copyright (C) 2019, Chongqing Medical University. Production and hosting by Elsevier B.V.
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