期刊
FOOD & FUNCTION
卷 11, 期 6, 页码 5205-5222出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0fo00007h
关键词
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资金
- National Natural Science Foundation of China, Beijing [31571813]
Some strains of lactobacilli can exert beneficial effects on a host when ingested in an adequate dose, such as immunoregulation and anti-inflammatory activities. In this study, the survival abilities under simulated gastrointestinal conditions, adhesion abilities on HT-29 cell monolayers, and hemolytic activities of fourLactobacillus plantarumstrains were assessed. Among the four strains,L. plantarum-12 showed the higher survival rate under simulated gastrointestinal conditions and adhesion index on the HT-29 cell monolayers, exhibited gamma-haemolytic activity and had no biological amine producing ability.L. plantarum-12 was administered to dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) Balb/c mice by oral gavage for 10 days. It was observed that the UC Balb/c mice showed symptoms of colonic atrophy, intestinal histopathological change, gut microbial disturbance, and pro-inflammatory cytokine expression.L. plantarum-12 administration remarkably attenuated DSS-induced UC in mice. L. plantarum-12 administration could restore gut microbiota by increasing beneficial bacteria such asLactobacillusand decreasing intestinal pathogenic bacteria likeProteobacteria. L. plantarum-12 administration could improve immunityviaactivating the janus kinase-signal transducer and the activator of the transcription (JAK-STAT) pathway and up-regulating adenosine deaminase (ADA) and interferon-induced protein with tetratricopeptide repeats 1 protein (IFIT1), and enforce the intestinal barrier function by up-regulating mucin 2 (MUC2) protein expression. In conclusion,L. plantarum-12 could attenuate DSS-induced UC in Balb/c mice by ameliorating intestinal inflammation, and restoring the disturbed gut microbiota.L. plantarum-12 could be used as promising probiotics to ameliorate colitis.
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