Comprehensive two-dimensional gas-chromatography to study the human exposome: Current trends and perspectives

In context of the exposome paradigm, the 'exposure' describes all individual and global environmental influences an individual throughout its entire lifetime. Cause, effect and their causality are the central research objectives, which require interdisci-plinary research strategies. The core benefits of comprehen-sive two-dimensional gas chromatography (GCxGC) make it a versatile technique for both exposure-and response-driven approaches, especially when combined with appropriate sample preparation and MS detection. In this article, the po-tentials and recent advances of GCxGC in the field of human exposome research is critically discussed.