4.6 Article

Forelimb Cortical Stroke Reduces Precision of Motor Control in Mice

期刊

NEUROREHABILITATION AND NEURAL REPAIR
卷 34, 期 6, 页码 475-478

出版社

SAGE PUBLICATIONS INC
DOI: 10.1177/1545968320921825

关键词

stroke; ischemic stroke; motor control; recovery; skilled reach; mouse

资金

  1. NIH [T32 NS069562, T32 GM113896, U24 NS107176]
  2. Patrick and Beatrice Haggerty Foundation
  3. Texas Institute for Brain Injury and Repair

向作者/读者索取更多资源

Background and Objective. Rodent models of stroke impairment should capture translatable features of behavioral injury. This study characterized poststroke impairment of motor precision separately from strength in an automated behavioral assay. Methods. We measured skilled distal forelimb reach-and-grasp motions within a target force range requiring moderate-strength. We assessed whether deficits reflected an increase in errors on only one or both sides of the target force range after photothrombotic cortical stroke. Results. Pull accuracy was impaired for 6 weeks after stroke, with errors redistributing to both sides of the target range. No decrease in maximum force was measured. Conclusions. This automated reach task measures sustained loss of motor precision following cortical stroke in mice.

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