期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 15, 期 13, 页码 1227-1235出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026615666150330111348
关键词
Self-assembly; Peptides; Nanostructures; Drug delivery; Encapsulation
资金
- CSIR Network Project [BSC 0120]
- DST Project [GAP 0104]
Self-assembled peptides and specifically small peptide based nanostructures have been the focus of research in past decade due to their potential biological applications. In this study, we prepared a protected peptide, Boc-Pro-Phe-Gly-OMe, which self-assembled in aqueous solutions leading to the formation of nanostructures and ability to act as a drug carrier. Dynamic light scattering (DLS) measurements showed nanostructures with average size of 119.6 nm containing hydrophobic core, wherein hydrophobic drugs, viz, eosin, aspirin and curcumin, were successfully encapsulated. These encapsulated nanostructures, were further stabilized with Vitamin E-TPGS. In-vitro drug release studies revealed the release of drugs in controlled fashion from the nanostructures. The results advocate the potential of the proposed peptide nanostructures as controlled drug delivery systems and could be used in other biomedical applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据