期刊
GREEN SYNTHESIS AND CATALYSIS
卷 1, 期 1, 页码 75-78出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.gresc.2020.06.001
关键词
Aryl boronic acids; C -N activation; Inactive amides; NHC-Palladacycle; Suzuki-Miyaura cross -coupling
Robust NHC-palladacycles (NHC =N-heterocyclic carbene) were synthesized and exhibited high catalytic activity towards Suzuki-Miyaura cross-coupling reactions between inactive amides with N-acetyl/benzyl substituents and aryl boronic acids, producing diverse ketones in good to excellent yields. This unprecedented and practical palladacycles-catalyzed Suzuki-Miyaura cross-coupling of amides with boronic acids via selective C-N bond activation was attributed to the strong & sigma;-donor and weak & pi;-acceptor properties of acenaphthoimidazolylidene, which may highlight their potential in other challenging coupling transformations involving inactive amides.
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