期刊
NEUROREHABILITATION AND NEURAL REPAIR
卷 34, 期 5, 页码 450-462出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1545968320913502
关键词
stroke; motor recovery; magnetoencephalography; beta-oscillations; event-related synchronization; event-related desynchronization
资金
- Taiwan Ministry of Science and Technology (MOST) [106-2314-B-075-019-MY3, 107-2634-F-008-003, 108-2634-F-008-003]
- Taipei Veterans General Hospital [V107C-064, V108C-052, V109C-034]
- Far Eastern Memorial Hospital [FEMH-2014-C-018, FEMH-2015-C-025]
- Taiwan Ministry of Education (Academic Strategic Alliance Project between Taiwan and Oxford University)
- National Yang-Ming University (Brain Research Center, from The Featured Areas Research Center Program by the Taiwan Ministry of Education)
- Sir Henry Dale Fellowship - Wellcome Trust
- Royal Society [102584/Z/13/Z]
Background. Recovery of upper limb function post-stroke can be partly predicted by initial motor function, but the mechanisms underpinning these improvements have yet to be determined. Here, we sought to identify neural correlates of post-stroke recovery using longitudinal magnetoencephalography (MEG) assessments in subacute stroke survivors. Methods. First-ever, subcortical ischemic stroke survivors with unilateral mild to moderate hand paresis were evaluated at 3, 5, and 12 weeks after stroke using a finger-lifting task in the MEG. Cortical activity patterns in the beta-band (16-30 Hz) were compared with matched healthy controls. Results. All stroke survivors (n=22; 17 males) had improvements in action research arm test (ARAT) and Fugl-Meyer upper extremity (FM-UE) scores between 3 and 12 weeks. At 3 weeks post-stroke the peak amplitudes of the movement-related ipsilesional beta-band event-related desynchronization (beta-ERD) and synchronization (beta-ERS) in primary motor cortex (M1) were significantly lower than the healthy controls (p<0.001) and were correlated with both the FM-UE and ARAT scores (r=0.51-0.69, p<0.017). The decreased beta-ERS peak amplitudes were observed both in paretic and non-paretic hand movement particularly at 3 weeks post-stroke, suggesting a generalized disinhibition status. The peak amplitudes of ipsilesional beta-ERS at week 3 post-stroke correlated with the FM-UE score at 12 weeks (r=0.54, p=0.03) but no longer significant when controlling for the FM-UE score at 3 weeks post-stroke.Conclusions. Although early beta-band activity does not independently predict outcome at 3 months after stroke, it mirrors functional changes, giving a potential insight into the mechanisms underpinning recovery of motor function in subacute stroke.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据