期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 36, 期 5, 页码 287-299出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/08830185.2017.1347649
关键词
Bacteria; gram negative; host immunity; microRNAs
类别
资金
- National Institutes of Health [1RO3AI11771401A1]
- Army Research Office, Department of Defense [W911NF-11-1-0136]
- National Institute of Child Health and Human Development Grant [HD061580]
Evidence over the last couple decades has comprehensively established that short, highly conserved, non-coding RNA species called microRNA (miRNA) exhibit the ability to regulate expression and function of host genes at the messenger RNA (mRNA) level. MicroRNAs play key regulatory roles in immune cell development, differentiation, and protective function. Intrinsic host immune response to invading pathogens rely on intricate orchestrated events in the development of innate and adaptive arms of immunity. We discuss the involvement of miRNAs in regulating these processes against gram negative pathogens in this review.
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