4.7 Article

Red-light-sensitive BODIPY photoprotecting groups for amines and their biological application in controlling heart rhythm

期刊

CHEMICAL COMMUNICATIONS
卷 56, 期 41, 页码 5480-5483

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc02178d

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资金

  1. Netherlands Organization for Scientific Research (NWO, VIDI) [723.014.001]
  2. Royal Netherlands Academy of Arts and Sciences Science (KNAW)
  3. Ministry of Education, Culture and Science [024.001.035]
  4. European Research Council (Advanced Investigator Grant) [694435]

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Control of biological function by the use of photoremovable protecting groups (PPGs) is a gateway towards many new medical developments. Herein, we report the synthesis and application of efficient and biocompatible BODIPY-based photoprotecting groups for amines, which are cleavable with red light in the phototherapeutic window region (lambda > 650 nm). We use the most promising PPG for the protection of dopamine and apply it to control the beating frequency of human cardiomyocytes.

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