期刊
ADVANCED THERAPEUTICS
卷 3, 期 5, 页码 -出版社
WILEY
DOI: 10.1002/adtp.201900110
关键词
drug delivery; mesoporous silica; protein corona; solid dosage forms; testosterone
资金
- ARC Centre of Excellence for Nanoscale BioPhotonics [CE140100003]
- ARC Future Fellowship (AEGB) [FT150100342]
- Macquarie University Infrastructure grant [MQRIBG-9201501951]
- Australian Government as part of the National Collaborative Research Infrastructure Strategy
- Australian Research Council [FT150100342] Funding Source: Australian Research Council
The formation of a protein corona adsorbed on mesoporous silica particles with 2D and 3D pore structures after incubation in fetal bovine serum is investigated. The compositional properties of the resulting protein-particle complex is determined by using mass spectrometry as a function of serum incubation time. The effect of the adsorbed proteins on the drug release properties of the mesoporous particles when these are used to deliver the hormone TST is examined in dissolution media. Changes to the pharmacokinetic parameters are validated in vivo in a rat model. Small changes to the maximum plasma concentration, terminal half-life, and area under the plasma concentration time curve are observed with pre-incubation of a hard protein corona around the particles. This strategy is used to slow down the release of pharmaceutical drugs loaded onto mesoporous silica, and acts as a formulation strategy for future nanomedical applications involving advanced drug delivery.
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