期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 18, 期 19, 页码 3659-3663出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob02724f
关键词
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资金
- JSPS KAKENHI [JP17H02207, JP18H04426, JP19H04815, JP19J13192, JP17H05800]
- AMED [JP19ae0101052, JP19gm0910010, JP19ak0101070, JP19fk0108075]
- Takeda Science Foundation
Ac1PIM1 is a potential biosynthetic intermediate for phosphatidylinositol mannosides (PIMs) from Mycobacterium tuberculosis. We achieved the first synthesis of Ac1PIM1 by utilizing an allyl-type protecting group strategy and regioselective phosphorylation of inositol. A very potent agonist of an innate immune receptor DCAR, which is better than previously known agonists, is demonstrated.
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