4.6 Article

The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: its synthesis and immunomodulatory function

期刊

ORGANIC & BIOMOLECULAR CHEMISTRY
卷 18, 期 19, 页码 3659-3663

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob02724f

关键词

-

资金

  1. JSPS KAKENHI [JP17H02207, JP18H04426, JP19H04815, JP19J13192, JP17H05800]
  2. AMED [JP19ae0101052, JP19gm0910010, JP19ak0101070, JP19fk0108075]
  3. Takeda Science Foundation

向作者/读者索取更多资源

Ac1PIM1 is a potential biosynthetic intermediate for phosphatidylinositol mannosides (PIMs) from Mycobacterium tuberculosis. We achieved the first synthesis of Ac1PIM1 by utilizing an allyl-type protecting group strategy and regioselective phosphorylation of inositol. A very potent agonist of an innate immune receptor DCAR, which is better than previously known agonists, is demonstrated.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据