期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 8, 期 20, 页码 4369-4386出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb00207k
关键词
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资金
- National Natural Science Foundation of China [21776044/21606041/21503035]
- Joint Research Fund Liaoning-Shenyang National Laboratory for Materials Science [2019JH3/30100011]
A clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein 9 (CRISPR/Cas9) system is the most widely used tool for gene editing. Due to the advantages of simple operation, high efficiency and high specificity, it has been used in various fields. In this review, we introduce the latest research in the delivery technology of CRISPR/Cas9 based on lipids and polymers, which are synthesized through chemical methods. Many successful examples and methods are discussed. In addition, we discuss the potential of these delivery systems used for CRISPR/Cas9 in clinical applications in the future.
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