期刊
CURRENT PHARMACEUTICAL DESIGN
卷 21, 期 10, 页码 1268-1271出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612821666141211115949
关键词
Glioblastoma; tumorigenesis; EMT; invasion; angiogenesis; FoxM1; Wnt/beta-catenin signaling
资金
- National Cancer Institute [R01CA157933, R01CA182684, R21CA152623, P50CA127001]
Glioblastoma multiforme (GBM) is one of the most malignant cancers in human brain. The prognosis of GBM is extremely poor because it is resistant to radiotherapy and chemotherapy. Improving understanding of the tumor biology brings some new hope to the treatment of GBM. In this review, we discuss the evidence that FoxM1 promotes the development and progression of GBM by regulating key factors involved in cell proliferation, epithelial to mesenchymal transition (EMT), invasion, angiogenesis and upregulating Wnt/beta-catenin signalling. Our recent experimental findings are also summarized to prove that FoxM1 is a novel therapeutic target against GBM.
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