期刊
CURRENT PHARMACEUTICAL DESIGN
卷 21, 期 16, 页码 2136-2146出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612821666150109122915
关键词
Molecular imaging; drug; therapy; antitumor; development
资金
- National Natural Science Foundation of China [81371572]
- Doctoral Program of Universities [2012440112000]
- China Postdoctoral Science Foundation [2013T60826]
- Science and Technology Liwan District [20124414124]
- Guangzhou Technology Bureau [12C22021645]
- Guangdong Science and Technology [2012B050300026]
- Natural Science Foundation of Guangdong Province [S2012040006593]
Molecular imaging enables noninvasive characterization, quantification and visualization of biological and pathological processes in vivo at cellular and molecular level. It plays an important role in drug discovery and development. The skillful use of molecular imaging can provide unique insights into disease processes, which greatly aid in identifications of target. Importantly, molecular imaging is widely applied in the pharmacodynamics study to provide earlier endpoints during the preclinical drug development process, since it can be applied to monitor the effects of treatment in vivo with the use of biomarkers. Herein, we reviewed the application of molecular imaging technologies in antitumor drug development process ranging from identification of targets to evaluation of therapeutic effect.
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