期刊
ANTIBIOTICS-BASEL
卷 9, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics9040161
关键词
E. coli; clonal structure; ST88; ST141; ST131; ST1193; virulence genes; resistance
资金
- Plan Estatal de I +D +I 2013-2016, Instituto de Salud Carlos III (ISCIII), Subdireccion General de Evaluacion y Fomento de la Investigacion, Ministerio de Economia y Competitividad (Gobierno de Espana) [PI16/01477]
- Fondo Europeo de Desarrollo Regional (FEDER)
- Conselleria de Cultura, Educacion e Ordenacion Universitaria, (Xunta de Galicia) [ED431C2017/57]
- FEDER
Escherichia coli is the main pathogen responsible for extraintestinal infections. A total of 196 clinical E. coli consecutively isolated during 2016 in Spain (100 from Lucus Augusti hospital in Lugo) and France (96 from Beaujon hospital in Clichy) were characterized. Phylogroups, clonotypes, sequence types (STs), O:H serotypes, virulence factor (VF)-encoding genes and antibiotic resistance were determined. Approximately 10% of the infections were caused by ST131 isolates in both hospitals and approximately 60% of these infections were caused by isolates belonging to only 10 STs (ST10, ST12, ST58, ST69, ST73, ST88, ST95, ST127, ST131, ST141). ST88 isolates were frequent, especially in Spain, while ST141 isolates significantly predominated in France. The 23 ST131 isolates displayed four clonotypes: CH40-30, CH40-41, CH40-22 and CH40-298. Only 13 (6.6%) isolates were carriers of extended-spectrum beta-lactamase (ESBL) enzymes. However, 37.2% of the isolates were multidrug-resistant (MDR). Approximately 40% of the MDR isolates belonged to only four of the dominant clones (B2-CH40-30-ST131, B2-CH40-41-ST131, C-CH4-39-ST88 and D-CH35-27-ST69). Among the remaining MDR isolates, two isolates belonged to B2-CH14-64-ST1193, i.e., the new global emergent MDR clone. Moreover, a hybrid extraintestinal pathogenic E.coli (ExPEC)/enteroaggregative isolate belonging to the A-CH11-54-ST10 clone was identified.
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