期刊
NATURAL PRODUCT REPORTS
卷 37, 期 5, 页码 609-616出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9np00052f
关键词
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资金
- Canadian Institutes of Health Research [CIHR: FDN-148366]
Covering: up to 2019 Pharmacological targeting of eukaryotic mRNA translation initiation is a promising approach for cancer therapy, since several signaling pathways that are commonly deregulated during tumor progression converge on this process. The DEAD-box helicase, eukaryotic initiation factor (eIF) 4A, is essential for translation initiation and facilitates the loading of the 43S pre-initiation complex onto mRNAs. Hippuristanol, rocaglates, and pateamine A are natural products that each target eIF4A by interfering with the helicase's RNA-binding activity in distinct manners. They exert a selective change in gene expression that results in potent anti-tumorigenic activity in pre-clinical studies. This review will provide an update on the molecular mechanisms of action of these natural products.
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