期刊
NATURAL PRODUCT REPORTS
卷 37, 期 5, 页码 653-676出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9np00057g
关键词
-
资金
- USDA NIFA [Hatch-NEV00727, Hatch-NEV00767]
- Dennis Meiss & Janet Ralston Fund for Nutri-epigenetic Research
- National Institute for General Medical Sciences (NIGMS) of the NIH [P20 GM130459]
- National Heart, Lung, and Blood Institute of the NIH [R15 HL143496]
- NSF EPSCOR Track II [OIA-1826801]
- Ohio State University Department of Physiology and Cell Biology
- National Institute of Aging [AG056848]
Covering: up to 2020 Chronic, low-grade inflammation is linked to aging and has been termed inflammaging. Inflammaging is considered a key contributor to the development of metabolic dysfunction and a broad spectrum of diseases or disorders including declines in brain and heart function. Genome-wide association studies (GWAS) coupled with epigenome-wide association studies (EWAS) have shown the importance of diet in the development of chronic and age-related diseases. Moreover, dietary interventions e.g. caloric restriction can attenuate inflammation to delay and/or prevent these diseases. Common themes in these studies entail the use of phytochemicals (plant-derived compounds) or the production of short chain fatty acids (SCFAs) as epigenetic modifiers of DNA and histone proteins. Epigenetic modifications are dynamically regulated and as such, serve as potential therapeutic targets for the treatment or prevention of age-related disease. In this review, we will focus on the role for natural products that include phytochemicals and short chain fatty acids (SCFAs) as regulators of these epigenetic adaptations. Specifically, we discuss regulators of methylation, acetylation and acylation, in the protection from chronic inflammation driven metabolic dysfunction and deterioration of neurocognitive and cardiac function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据