期刊
CURRENT PHARMACEUTICAL DESIGN
卷 21, 期 9, 页码 1118-1123出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612820666141013162528
关键词
Atherosclerosis; arteriosclerosis; arteries; inflammation; dendritic cells; plasmacytoid dendritic cells
资金
- Russian Scientific Foundation, Russian Federation [14-15-00112]
Functional heterogeneity of dendritic cells (DCs) observed in atherosclerosis suggest for their complex and multifaced role in the pathogenesis of atherosclerotic disease. A delicate balance between anti-inflammatory and pro-inflammatory mechanisms drives atherogenesis, and local microenvironment triggers the actual involvement of DCs in atherosclerosis-associated inflammation. Responding to microenvironment stimuli, DCs contribute to atherogenesis in both ways being involved in supporting proatherogenic vascular inflammation and by suppressing inflammatory responses via induction of self-tolerogenic properties and regulatory T cells (Tregs). The local microenvironment and extrinsic stimuli influence DC phenotype and hence could control the phenotypic switch toward inflammation or tolerance.
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