期刊
CHEMICAL SCIENCE
卷 11, 期 21, 页码 5410-5414出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sc01817a
关键词
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资金
- NNSF of China [21675130, 21775124, 21974108]
- Natural Science Foundation Project of CQ CSTC [cstc2018jcyjAX0546]
- Fundamental Research Funds for the Central Universities [XDJK2019TJ002]
Electrochemiluminescence (ECL) micro-reactors with enhanced intensity and extreme stability were first established by the assembly of tris(2,2'-bipyridyl) ruthenium(II) (Ru(bpy)(3)(2+)) onto covalent organic frameworks (COFs), in which a type of imine-linked COF (denoted as COF-LZU1) was employed as a model for ECL micro-reactors. Compared with the dominant ECL system of Ru(bpy)(3)(2+) tri-n-propylamine (TPrA) (TPrA as a co-reactant), the intensity of the COF-LZU1 micro-reactor-based electrode was significantly increased nearly 5-fold under the same experimental conditions, which is unprecedented in other Ru(bpy)(3)(2+)-based ECL systems. This enhancement can be attributed to the large surface area, delimited space, and stable and hydrophobic porous structure of COF-LZU1, which not only enabled a huge amount of Ru(bpy)(3)(2+) to be loaded in/on COF-LZU1, but also enriched a large amount of TPrA from the aqueous solution into its inner hydrophobic cavity due to the lipophilicity of TPrA. More importantly, with its hydrophobic porous nanochannels, COF-LZU1 could act as micro-reactors to provide a delimited reaction micro-environment for the electrochemical oxidation of TPrA and the survival of TPrA(center dot), achieving significant confinement-enhanced ECL. To prove this principle, these Ru@COF-LZU1 micro-reactors were developed to prepare an ECL aptasensor for aflatoxin M1 (AFM1) detection with a wide detection range and a low detection limit. Overall, this work is the first report in which ECL micro-reactors are constructed with COFs to enhance the intensity and stability of the Ru(bpy)(3)(2+)-based ECL system, and opens a new route to the design of other ECL micro-reactors for bioanalysis applications.
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