期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 8, 期 21, 页码 4587-4592出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb02685a
关键词
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资金
- National Natural Science Foundation of China [21671064]
- Science and Technology Planning Project of Hunan Province [2017RS3031]
- Scientific Research Fund of Hunan Provincial Education Department [19A329]
- Natural Science Foundation of Hunan Province, China [2019JJ10002]
- Hunan Provincial Innovation Foundation For Postgraduates [CX2018B238]
Silk fibroin-based materials spun by silkworms present excellent biocompatible and biodegradable properties, endowing them with broad applications for use in in vivo implanted devices. Therefore, it is highly desirable to explore functionalized silk with additional optical bioimaging abilities for the direct in situ monitoring of the status of implanted devices in vivo. Herein, a new type of silk material with a second near-infrared (NIR-II, 1000-1700 nm) emission is explored for the real-time observation of a biological stent model using a general route of feeding larval silkworms with lanthanide-based NaYF4:Gd3+/Yb3+/Er3+@SiO2 nanocrystals. After being fed lanthanide nanocrystals, the silk spun by silkworms shows efficient NIR-II emission beyond 1500 nm. Moreover, NIR-II bio-imaging guided biological stent model monitoring presents a superior signal-to-noise (S/N) ratio compared to the traditional optical imaging by utilizing the upconversion (UC) region. These findings open up the possibility of designing NIR-II optically functionalized silk materials for highly sensitive and deep-tissue monitoring of the in vivo states of the implanted devices.
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