期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 8, 期 21, 页码 4672-4679出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb00326c
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Zein-based filaments containing 20 weight% [Lidocainium][Ibuprofenate] used as a doubly Active Pharmaceutical Ingredient-Ionic Liquid (API-IL) were obtained by extrusion at 130 degrees C. The plasticizing effect of the active ingredient on the zein amorphous matrix was assessed by differential scanning calorimetry, with a decrease in the glass transition temperature (T-g) from 77 degrees C, for the raw zein, to 53 degrees C. After storage under standard conditions (relative humidity 59%, 20 degrees C) the extrudates were rigid, with a high storage modulus (E ') of about 3 GPa at ambient temperature. They had a main mechanical relaxation (T-alpha) beginning at 55 degrees C, leading to their flowing at temperatures above 130 degrees C, as determined by dynamic mechanical analysis, with E ' below 1 MPa and tan delta above 1. Their structure was evaluated by wide angle X-ray scattering and NMR analysis was used to evaluate the API-IL stability after thermomechanical processing. Release experiments performed under simulated physiological conditions on filaments evidenced a release of 85% after 7 days immersion. These results demonstrate the advantage of using an API-IL as plasticizer of a resorbable biopolymer. The resulting material can be shaped by a continuous thermomechanical process and used as a drug delivery system.
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