期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 16, 期 8, 页码 733-737出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389201016666150505121951
关键词
Anti-biofilm activity; Anti-quorum sensing effects; Flavonoids; Pseudomonas aeruginosa PAO1
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [173032, 172015, 172053]
This work was focused on in vitro evaluation of anti-biofilm and anti-quorum sensing effects of four selected flavonoid compounds /(+)-catechin, caffeic acid, quercetin and morin/using the strain Pseudomonas aeruginosa PAO1. At a concentration of 0.5 MIC quercetin was the only compound found to potently reduce both P. aeruginosa biofilm formation (95%) and its twitching motility. The chemical scaffold of quercetin, a common dietary polyphenol, may actually inspire development of novel and more effective medicinal agents targeting P. aeruginosa, the bacterium well known for its resistance.
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